The purpose of this study is to continue to collect data on the safety and effectiveness of a medical device called the Paradise Ultrasound Renal Denervation System (also called the Paradise System) in patients who are known to have uncontrolled hypertension despite taking blood pressure-lowering medications. Previous research supports the continued study of the Paradise System. This study will collect additional safety data and efficacy data (i.e., the blood pressure lowering effect) in patients with uncontrolled hypertension. All patients who meet enrollment criteria will receive renal denervation treatment in this non-randomized study. Renal denervation is a minimally invasive procedure in which a catheter is used to send ultrasound or heat energy to the renal arteries. Results from the study may be used to help the U.S. Food and Drug Administration (FDA) determine whether the device should be approved in the United States.