This study focuses on adults who have obstructive hypertrophic cardiomyopathy (oHCM), abnormally thick heart muscle, and left ventricular outflow tract (LVOT) obstruction (a condition which interferes with the flow of blood in the heart). The study is designed to evaluate the tolerability and safety of an investigational drug called CK-3773274. CK-3773274 may reduce symptoms of oHCM by reducing LVOT obstruction. The study will compare the effects of CK-3773274 with placebo (inactive substance) to learn how well the drug is tolerated in patients with oHCM and whether it causes any side effects. The study will also examine the amount of CK-3773274 in the blood at various times and the effect it may have on the patient's oHCM. Additionally, researchers aim to determine the optimal dose level of CK-3773274.
What is the full name of this clinical trial?
A MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-FINDING STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF CK3773274 IN ADULTS WITH SYMPTOMATIC HYPERTROPHIC CARDIOMYOPATHY AND LEFT VENTRICULAR OUTFLOW TRACT OBSTRUCTION