The FDR's proband was enrolled in the DCM Precision Medicine Study at 1 of 9 participating sites, or exceptions granted by study PI.
The FDR's proband has had one or more variants identified, including P, LP and VUS.
The FDR is able report to one of the participating sites for study enrollment.
The FDR has no current contraindication for CMR (glomerular filtration rate (GFR) <30 mL/min/1.73 m2, non-compatible device implant, or allergy to gadolinium contrast).
The FDR has had no prior heart transplant.
The FDR is ≥18 years of age.
Ability to give informed consent.
Ability to communicate in English.
Subject is not pregnant (CMR may be conducted 3-6 months post delivery)
Willingness to participate in a family-based study (subject willing to interact with OSU).
Coronary artery disease (CAD) causing ischemic cardiomyopathy (> 50% narrowing, any major epicardial coronary artery).
Primary valvular disease.
Adriamycin or other cardiotoxic drug exposure.
Other forms of cardiomyopathy: Hypertrophic, Restrictive, or Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy.
Congenital heart disease.
Other detectable causes of dilated cardiomyopathy, including sarcoid and hemochromatosis.
Other active multisystem disease, even if very rare, that may plausibly cause DCM (e.g., hypereosinophilic syndrome, cardiac involvement with connective tissue disease, Loeffler's endocarditis, endomyocardial fibrosis, etc) are excluded. Please call the PI to discuss if uncertain or not clear.
Severe and untreated or untreatable hypertension (systolic blood pressures routinely greater than 180 mm Hg and/or diastolic blood pressures greater than 120 mm Hg, and if resistant to multidrug treatment). This includes profound hypertension associated with other multisystem disease (e.g., scleroderma, other vasculitides, etc).