What is the Purpose of this Study?
This study focuses on individuals who have had a recent (within 6 weeks) stroke and have no known history of dementia. The purpose of the study is to learn more about the factors that make people more or less likely to develop dementia (decline in memory, thinking, and other mental abilities that significantly affects daily functioning) after having a stroke. The study aims to identify patients at risk for dementia after their stroke so that future treatments may be developed to improve outcomes in stroke patients.
For this study, a stroke is defined as an ischemic stroke (blood clot in the brain), intracerebral hemorrhage (bleeding in the brain), or an aneurysmal subarachnoid hemorrhage (bleeding around the brain caused by an abnormal bulge in a blood vessel that bursts). Researchers will review participants’ medical records and collect blood samples, as well as conduct interviews, physical and neurological exams, and cognitive assessments.
Eligibility
- 1. Age ≥18 years
- 2. Admitted to the enrolling clinical performance site (CPS) hospital with a diagnosis of acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), or aneurysmal subarachnoid hemorrhage (aSAH)
- 3. Radiographic confirmatory evidence of: (1) AIS (based on a focal area of restricted diffusion on MRI), (2) non-traumatic primary ICH (based on evidence of acute parenchymal hemorrhage on CT or brain MRI) or (3) non-traumatic acute aSAH (based on evidence of subarachnoid hemorrhage on CT or MRI and evidence of aneurysm on CT angiography, MR angiography, or conventional catheter-based angiography)
- 4. Able to complete baseline visit in person or by phone within 6 weeks of stroke onset
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Inclusion Criteria:
- 1. Age ≥18 years
- 2. Admitted to the enrolling clinical performance site (CPS) hospital with a diagnosis of acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), or aneurysmal subarachnoid hemorrhage (aSAH)
- 3. Radiographic confirmatory evidence of: (1) AIS (based on a focal area of restricted diffusion on MRI), (2) non-traumatic primary ICH (based on evidence of acute parenchymal hemorrhage on CT or brain MRI) or (3) non-traumatic acute aSAH (based on evidence of subarachnoid hemorrhage on CT or MRI and evidence of aneurysm on CT angiography, MR angiography, or conventional catheter-based angiography)
- 4. Able to complete baseline visit in person or by phone within 6 weeks of stroke onset
- 5. Able to provide informed consent by self or proxy
- 6. Fluent in English or Spanish prior to stroke onset
Exclusion Criteria:
- 1. Documented history of pre-stroke dementia or fails dementia pre-screen
- 2. Concurrently enrolled into a study that is not approved under the DISCOVERY Co-Enrollment Policy
- 3. Unable to complete study protocol (advanced directives such as comfort measures only, or inability to complete the study due to severe medical/behavioral co-morbidities), as determined by physician investigator during screening process
- 4. Contraindication to MRI: presence of electrically, magnetically, or mechanically activated implants (such as cardiac pacemakers, cochlear implants, implanted pumps); or metallic clips in the brain
- 5. Age \<50 years
- 6. Biologically female individuals who are pregnant or seeking to become pregnant
- 7. Known to have one of the following genetic conditions which can increase the risk of developing cancer: Cowden disease, Lynch syndrome, hypogammaglobulinemia, Wiskott-Aldrich syndrome, Down's syndrome.
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Where can I participate?
Beverly
More about this Clinical Trial
What is the full name of this clinical trial?
DETERMINANTS OF INCIDENT STROKE COGNITIVE OUTCOMES AND VASCULAR EFFECTS ON RECOVERY