The purpose of this study is to evaluate whether pain relief can be achieved using only 1-2 radiation treatments to a painful bone lesion in patients with multiple myeloma (MM). Bone disease is common in MM patients. Radiotherapy is effective in providing some degree of pain relief from multiple myeloma related bone disease, but there is no consensus as to the most effective dose or how many treatments help lessen the pain from bone lesions. Shorter courses of radiotherapy are not only more convenient for patients and their families but interfere less with the timing of chemotherapy. Pain assessment will be conducted by asking participants about their pain level and quality of life. If patients do not achieve pain relief after only 1 or 2 treatments at 4 weeks following radiotherapy, additional radiotherapy without additional side effects could be given, with the goal of achieving pain relief.