HC-7366 in Combination With Belzutifan in Renal Cell Carcinoma

What is the Purpose of this Study?

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called HC-7366 in combination with another drug, belzutifan (also known as MK-6482) in people who have inoperable or metastatic renal cell carcinoma (RCC, a type of kidney cancer). The study focuses on RCC patients whose condition has worsened after treatment with at least 2 but no more than 5 previous chemotherapies or other therapy. Researchers aim to understand how well HC-7366 and belzutifan work together and how safe they are in these patients, in addition to identifying the highest tolerable dose. Belzutifan is approved by the U.S. Food and Administration (FDA) for the treatment of adults with advanced renal cell carcinoma (RCC).


Eligibility

  • * Has diagnosis of locally advanced (inoperable) or metastatic RCC with a predominant clear cell component
  • * Be age 18 years or older (male or female) at the time of consent
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Where can I participate?

  • CS Cancer at Beverly Hills
  • CS Cancer at Cedars-Sinai Medical Center


More about this Clinical Trial

What is the full name of this clinical trial?

HC366-RCC2311: A Phase 1b, Open-Label, Safety, Tolerability, and Efficacy Study of HC7366 in Combination with Belzutifan in Patients with Locally Advanced or Metastatic Renal Cell Carcinoma

Study Details
Disease Type/Condition

Kidney

Principal Investigator

Figlin, Robert

Co-Investigators

David Hoffman, Edwin Posadas, Jun Gong, Kevin Scher

Age Group

Adult

Phase

I

IRB Number

STUDY00003265

ClinicalTrials.gov ID

NCT06234605

Key Eligibility
ClinicalTrials.gov

How do I learn more about this study?
Email
clinicaltrials@cshs.org
Study Detail
Disease Type/Condition

Kidney

Principal Investigator

Figlin, Robert

Age Group

Adult

Phase

I

IRB Number

HC366-RCC2311/MK-6482-030

ClinicalTrials.gov ID

NCT06234605

Key Eligibility
ClinicalTrials.gov

Contact
Email
clinicaltrials@cshs.org