The purpose of this study is to evaluate the long-term effect of risk-reducing, bilateral salpingo-oophorectomy (removal of fallopian tubes and ovaries) on health outcomes in women with genetic mutations known to increase the risk for cancer. The study will assess changes in cognitive function, bone health, cardiovascular disease, quality of life, and frequency of screening procedures in women at an elevated risk of cancer.  Participants will undergo physical exams, lab tests and DEXA scans (scans to assess bone density); they will also complete pre- and postoperative questionnaires.