Identification of Pre-Malignant Lesions In Pediatric Patients With Neurofibromatosis Type 1

What is the Purpose of this Study?

The purpose of this study is to evaluate the use of a magnetic resonance imaging (MRI) technique called whole-body MRI, combined with a computer program, in children and adolescents (5-18 years old) with neurofibromatosis type 1 (NF-1). The whole-body MRI with computer program is a technique that looks head-to-knee for suspicious tumors and can be completed more quickly than the standard MRI, even with patient movement. Individuals with NF-1 are recommended to have one whole-body MRI between 16-20 years old. Researchers aim to determine whether it is feasible to complete whole-body MRIs, using this novel technique paired with the computer program, to predict cancerous and non-cancerous tumors in young patients affected by NF-1.


Eligibility

  • Between the ages of 5 and <18 years at the start of study. If subject will turn 18 during the study, they will be allowed to enroll.
  • Clinically or molecularly confirmed diagnosis of NF-1. Subjects with mosaic/segmental NF-1 also qualify for the study.
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Where can I participate?

Cedars-Sinai Cancer at SOCC

More about this Clinical Trial

What is the full name of this clinical trial?

IIT2020-23-Baca-MRINF1: Identification of Pre-Malignant Lesions In Pediatric Patients With Neurofibromatosis Type 1 Using Novel Magnetic Resonance Imaging Techniques Paired With Artificial Intelligence ^*

Study Details
Disease Type/Condition

Brain and Nervous System

Principal Investigator

Baca, Nicole

Co-Investigators

Edwin Posadas, Fataneh Majlessipour, Leo Mascarenhas, Pedro Sanchez, Touseef Ahmad Qureshi, Yibin Xie

Age Group

Children

Phase

N/A (Cancer Control)

IRB Number

STUDY00001285

ClinicalTrials.gov ID

NCT04763109

Key Eligibility
ClinicalTrials.gov

How do I learn more about this study?
Email
clinicaltrials@cshs.org
Study Detail
Disease Type/Condition

Brain and Nervous System

Principal Investigator

Baca, Nicole

Age Group

Children

Phase

N/A (Cancer Control)

IRB Number

IIT2020-23-BACA-MRINF1

ClinicalTrials.gov ID

NCT04763109

Key Eligibility
ClinicalTrials.gov

Contact
Email
clinicaltrials@cshs.org