The purpose of this study is to examine the effects of an 18-week ketogenic diet (high fat, moderate protein, very low carbohydrate diet) on overall survival of glioblastoma (a type of brain cancer). Researchers also aim to learn how biomarkers change when consuming a ketogenic diet. A biomarker is a biological molecule found in blood, other body fluids or tissues that may be a sign of a condition or disease and can be used to predict response to a specific treatment. Participants will be randomized into 1 of 2 groups. Group 1 will eat their usual diet, and Group 2 will eat a ketogenic diet. Both groups will receive regular diet advice and support from a trained study dietitian. Participants will also be asked to complete surveys, among other study procedures.
What is the full name of this clinical trial?
IIT2022-06-HU-DIET2TREAT: A Randomized Controlled Phase 2 Study of the Ketogenic Diet versus Standard Anti-Cancer Dietary Guidance for Patients with Newly Diagnosed Glioblastoma in Combination with Standard-of-Care Treatment
Chirag Patil, Gillian Gresham, Jeremy Rudnick, John Yu, Lauren J Amaral, Ray Chu, Stephen Freedland, Stephen Shiao, You Sungyong