Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography

What is the Purpose of this Study?

The purpose of this study is to determine whether an imaging scan called a Sodium Fluoride Cardiac PET/MRI (18F-NaF PET/MRI) can detect early injury to heart blood vessels (coronary arteries) in patients with stage II-IV cancer who have increased risk of cardiovascular dysfunction after treatment with radiation therapy near the heart. Radiation therapy is an important part of treatment for many cancers, but it can cause some unwanted consequences such as cardiac dysfunction, coronary artery disease, and heart failure. 18F-NaF PET/MRI is a type of imaging scan that is injected to help take a detailed picture to potentially identify high-risk coronary artery plaques or areas of injury. Study procedures include a 18F-NaF cardiac PET/MRI scan and coronary computed tomography angiogram (CT with iodinated contrast to look at heart blood vessels). Researchers hope that by using 18F-NaF Cardiac PET/MRI imaging, they can sooner identify patients at risk of serious cardiac dysfunction earlier after radiation therapy, resulting in better outcomes. The use of 18F-NaF PET/MRI in this study is experimental.


Eligibility

  • * Age ≥ 18 years.
  • * Have clinical stage II-III or oligo-metastatic stage IV malignancy (any histology) planned to be treated with thoracic radiotherapy (≥30 Gy) where the heart is in the treatment field.
  • * Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-2.
  • * Planning to receive standard of care radiotherapy treatment.
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Where can I participate?

CS Cancer at Cedars-Sinai Medical Center : Ana Martin

More about this Clinical Trial

What is the full name of this clinical trial?

IIT2023-08-ATKINS-ATHERO-RT: Real-Time Atherosclerosis Activity after Thoracic Radiotherapy using Sodium Fluoride Positron Emission Tomography

Study Details
Disease Type/Condition

Thoracic Cancers

Principal Investigator

Atkins, Katelyn

Co-Investigators

Alan Kwan, Amin Mirhadi, Celeste Eno, Eric Vail, Stephen Shiao

Age Group

Adult

Phase

N/A

IRB Number

STUDY00003418

ClinicalTrials.gov ID

NCT06373497

Key Eligibility
ClinicalTrials.gov

How do I learn more about this study?
Name

Ana Martin

Email
ana.martin@cshs.org
Study Detail
Disease Type/Condition

Thoracic Cancers

Principal Investigator

Atkins, Katelyn

Age Group

Adult

Phase

N/A

IRB Number

IIT2023-08-ATKINS-ATHERO-RT

ClinicalTrials.gov ID

NCT06373497

Key Eligibility
ClinicalTrials.gov

Contact
Name

Ana Martin

Email
ana.martin@cshs.org