What is the Purpose of this Study?
This study focuses on women who have estrogen receptor-positive breast cancer with axillary nodal disease (cancer that has spread to a lymph node). The purpose of the study is to determine the safety and effectiveness of targeted axillary dissection (TAD) with sentinel node biopsy (SNB) in these patients. Researchers want to determine whether TAD/SNB leads to acceptable disease control and survival outcomes, while avoiding the risks of axillary lymph node dissection (ALND). The usual procedure is ALND, which can cause swelling, typically in the arm, hand, chest, back, breast, or underarm area, which may cause pain or discomfort or limit movement. TAD/SNB is a more limited lymph node surgery, which may decrease the risk of lymphedema. Participants will undergo is breast surgery (breast conserving surgery or mastectomy) with TAD/SNB. If needed, they will undergo subsequent ALND and/or an additional surgery to clear margins.
Eligibility
- * Women age ≥ 45
- * Clinical T1-2N0 ER+ invasive breast cancer
- * US detected biopsy proven axillary nodal disease
- * Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
Where can I participate?
- CS Cancer Tarzana : Nikki Kem-Bernard
- CS Cancer at Cedars-Sinai Medical Center : Nikki Kem-Bernard
More about this Clinical Trial
What is the full name of this clinical trial?
IIT2023-09-Chung-UpfrontTAD: Upfront TAD/SNB in Patients with Clinical T1-2N0 ER+ Her2- Breast Cancer with Ultrasound Detected Nodal Metastases