2.1 PRIMARY OBJECTIVE Aim 1 (Outcomes). (a) Tests how AVOID and RESIST affect weight loss (primary) and diet quality (secondary). H1a: AVOID and/or RESIST (arms, 2, 3, 4) will result in greater weight loss at 6-month and 12-month timepoints compared to WW alone. (b) Tests potential ripple effects of AVOID and RESIST on available household members diet quality (primary) and weight (secondary). H1b: Inasmuch as AVOID targets the home and RESIST focuses on the individual, we predict that AVOID (arms 2 and 4) will produce greater dietary changes in household members than WW alone and RESIST (arms 1 and 3). 2.2 SECONDARY OBJECTIVE Aim 2 (Mechanisms). Tests the mechanistic pathways of AVOID and RESIST by (a) comparing longitudinal changes in inhibitory control and home food environment across study arms; and (b) whether inhibitory control and home food environment mediate the relationships between study arms and anthropometric and dietary outcomes. H2: AVOID will produce changes in home food environment and RESIST will operate on inhibitory control. Aim 3 (Moderators). Examines how (a) individual characteristics (demographics and baseline executive functioning, physical activity and weight), and (b) process data (frequency of grocery delivery, dining out and take out, impulse control training and WW app use) moderate the relationship between study arms and anthropometric and dietary outcomes. These considerations are important to help explain heterogeneity in intervention outcomes and to understand who benefits from AVOID and/or RESIST.
What is the full name of this clinical trial?
IIT2025-SALVY-AVOID-RESIST: Evaluating environmental control and inhibitory control strategies to improve weight management outcomes