CSMC, IIT2025-SALVY-AVOID-RESIST, Weight management

What is the Purpose of this Study?

2.1 PRIMARY OBJECTIVE Aim 1 (Outcomes). (a) Tests how AVOID and RESIST affect weight loss (primary) and diet quality (secondary). H1a: AVOID and/or RESIST (arms, 2, 3, 4) will result in greater weight loss at 6-month and 12-month timepoints compared to WW alone. (b) Tests potential ripple effects of AVOID and RESIST on available household members diet quality (primary) and weight (secondary). H1b: Inasmuch as AVOID targets the home and RESIST focuses on the individual, we predict that AVOID (arms 2 and 4) will produce greater dietary changes in household members than WW alone and RESIST (arms 1 and 3). 2.2 SECONDARY OBJECTIVE Aim 2 (Mechanisms). Tests the mechanistic pathways of AVOID and RESIST by (a) comparing longitudinal changes in inhibitory control and home food environment across study arms; and (b) whether inhibitory control and home food environment mediate the relationships between study arms and anthropometric and dietary outcomes. H2: AVOID will produce changes in home food environment and RESIST will operate on inhibitory control. Aim 3 (Moderators). Examines how (a) individual characteristics (demographics and baseline executive functioning, physical activity and weight), and (b) process data (frequency of grocery delivery, dining out and take out, impulse control training and WW app use) moderate the relationship between study arms and anthropometric and dietary outcomes. These considerations are important to help explain heterogeneity in intervention outcomes and to understand who benefits from AVOID and/or RESIST.


Eligibility

  • * Age 18 years or older
  • * BMI between 25-45 kg/m2
  • * Read, write, and speak English with acceptable visual acuity
  • * Has a household member (≥ 14 years) willing to complete three brief assessments over 12 months\* \*Only applies to individuals who indicate they are cohabitating with at least one eligible household member
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Where can I participate?

CS Cancer at Cedars-Sinai Medical Center

More about this Clinical Trial

What is the full name of this clinical trial?

IIT2025-SALVY-AVOID-RESIST: Evaluating environmental control and inhibitory control strategies to improve weight management outcomes

Study Details
Disease Type/Condition

Other

Principal Investigator

Salvy, Sarah

Age Group

Adult

Phase

N/A

IRB Number

STUDY00001652

ClinicalTrials.gov ID

NCT05143931

Key Eligibility
ClinicalTrials.gov

How do I learn more about this study?
Email
clinicaltrials@cshs.org
Study Detail
Disease Type/Condition

Other

Principal Investigator

Salvy, Sarah

Age Group

Adult

Phase

N/A

IRB Number

IIT2025-SALVY-AVOID-RESIST

ClinicalTrials.gov ID

NCT05143931

Key Eligibility
ClinicalTrials.gov

Contact
Email
clinicaltrials@cshs.org