What is the Purpose of this Study?
Primary -To evaluate the safety and tolerability and determine the MTD and/or RDE(s) of INCB177054 as a single agent and in combination retifanlimab. Secondary -To determine the preliminary efficacy of INCB177054 as a single agent or in combination with retifanlimab. Exploratory -To evaluate the PK of INCB177054 as a single agent and in combination with retifanlimab. -To explore the pharmacodynamic effects of INCB177054 as a single agent or in combination with retifanlimab in tumor tissue, blood, or plasma. -To explore the relationship between INCB177054 exposure and response in participants with selected advanced or metastatic solid tumors. -To explore the relationship between INCB177054 exposure and safety in participants with selected advanced or metastatic solid tumors.
Eligibility
Where can I participate?
CS Cancer at The Angeles Clinic and Research Institute : Marquis Keene, Saba Mukarram
More about this Clinical Trial
What is the full name of this clinical trial?
A Phase 1/2, Open-Label, Multicenter Study of INCB177054 in Participants With Select Advanced or Metastatic Solid Tumors