ABBV-383 Compared With Standard Available Therapies in Relapsed or Refractory Multiple Myeloma

What is the Purpose of this Study?

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called ABBV-383 in people with relapsed or refractory multiple myeloma (multiple myeloma that has come back or did not get better) who have received at least 2 prior lines of therapy. Researchers will evaluate whether treatment with ABBV-383 is safe, well-tolerated, and works better than the current standard available therapies to treat multiple myeloma. A previous study already showed that ABBV-383 is safe and effective for the majority of patients with relapsed multiple myeloma, but it is unknown how it compares to currently approved medications. Participants will be randomly assigned to 1 of 2 groups. One group will receive ABBV-383, and the other will receive standard available therapy.


Eligibility

  • * Eastern Cooperative Oncology Group (ECOG) performance of \<= 2.
  • * Diagnosis of relapsed/refractory (R/R) multiple myeloma (MM) during or after the participant's last treatment as stated in the protocol.
  • * Must have measurable disease with at least 1 of the following assessed within 28 days of enrollment:
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Where can I participate?

CS Cancer at Cedars-Sinai Medical Center : Emilie Douine-Barthelemy

More about this Clinical Trial

What is the full name of this clinical trial?

M22-574: A Phase 3, Multicenter, Randomized, Open-Label Study of ABBV-383 Compared with Standard Available Therapies in Subjects with Relapsed or Refractory Multiple Myeloma *

Study Details
Disease Type/Condition

Multiple Myeloma

Principal Investigator

Oveisi, David

Co-Investigators

Akil Merchant, Hannah Lee, Joshua Sasine, Justin Darrah, Noah Merin, Robert Vescio, Ronald Paquette

Age Group

Adult

Phase

III

IRB Number

STUDY00003270

ClinicalTrials.gov ID

NCT06158841

Key Eligibility
ClinicalTrials.gov

How do I learn more about this study?
Name

Emilie Douine-Barthelemy

Email
emilie.douine-barthelemy@cshs.org
Study Detail
Disease Type/Condition

Multiple Myeloma

Principal Investigator

Oveisi, David

Age Group

Adult

Phase

III

IRB Number

M22-574

ClinicalTrials.gov ID

NCT06158841

Key Eligibility
ClinicalTrials.gov

Contact
Name

Emilie Douine-Barthelemy

Email
emilie.douine-barthelemy@cshs.org