Spontaneous intracranial hypotension (SIH) is a neurological disorder caused by a spinal cerebrospinal fluid leak (when fluid that surrounds the brain and spinal cord leaks), leading to severe headache and other neurological symptoms. The purpose of this prospective study is to collect data on patients diagnosed with SIH to understand patient outcomes after interventions such as blood patching (use of the patient’s own blood to close a hole), fibrin glue injections (glue injected to promote healing and sealing tissue), endovascular embolization (medical procedure used to block off abnormal connections between veins and CSF pathways), and spine surgery shortly after these interventions, as well as months and up to 5 years later. Study procedures include data collection from medical records and completion of questionnaires by patients at various time points. Outcomes will include scales assessing clinical changes, disability, depression, anxiety, quality of life, and a global assessment of change. Understanding patients’ short-term and long-term outcomes is important for a better understanding of this complex condition, particularly as little prospective research currently exists on patient outcomes.