What is the Purpose of this Study?
The purpose of this study is to compare 2 radiation schedules that can be used to treat patients with high-risk prostate cancer. One approach delivers a higher dose of radiation per treatment and uses fewer treatments over a shorter length of time (called stereotactic body radiation therapy-SBRT). The other delivers a lower dose of radiation per treatment but for more treatments over a longer time, which is a more standard approach. SBRT delivers the high dose of radiation more precisely to the tumor to spare normal tissue. The study will determine whether a higher dose/shorter course treatment is as effective as the lower dose/longer course treatment plan. Participants will be randomly assigned to 1 of 2 groups: the study approach (higher dose/shorter course), or the usual radiation therapy (lower dose/longer course).
Eligibility
- * Pathologically (histologically or cytologically) proven diagnosis of adenocarcinoma of prostate cancer
- * High-risk disease defined as having at least one or more of the following:
- * cT3a-T3b by digital exam or imaging (American Joint Committee on Cancer \[AJCC\] 8th edition \[Ed.\]) Note: cT4 by imaging or on digital rectal exam is not allowed
Where can I participate?
- CS Cancer at Beverly Hills : Maria Tarallo
- CS Cancer at Cedars-Sinai Medical Center : Maria Tarallo
More about this Clinical Trial
What is the full name of this clinical trial?
NRG-GU013: The Phase III High Five Trial Five Fraction Radiation For High-Risk Prostate Cancer