CSMC_Metabolic Outcomes in Craniopharyngiomas

What is the Purpose of this Study?

Overall research plan: We propose a prospective pilot study of GH replacement in patients with adult-onset CP and confirmed GHD beginning 3-6 months after surgical tumor resection. We hypothesize that early GH replacement in adult-onset CP will improve measures of body composition, glycemia, and hepatic steatosis as well as AT function. Aim 1: Measure effect of early GH replacement on body composition, glycemia, and hepatic steatosis. Hypothesis: GH replacement will reverse increased fat mass, insulin resistance, and NAFLD that develop early after surgery. Aim 2: Characterize effect of GH replacement on changes in adipocyte morphology and AT function. Hypothesis: GH replacement will reduce adipocyte size, adipokine secretion, and markers of inflammation and increase lipolysis in AT.


Eligibility

Not Available


Where can I participate?

Beverly


What is the full name of this clinical trial?

METABOLIC OUTCOMES IN CRANIOPHARYNGIOMAS

Study Details
Disease Type/Condition

Other

Principal Investigator

Cooper, Odelia

Age Group

Adult

Phase

N/A

IRB Number

STUDY00001615


How do I learn more about this study?
Email
clinicaltrials@cshs.org
Study Detail
Disease Type/Condition

Other

Principal Investigator

Cooper, Odelia

Age Group

Adult

Phase

N/A

IRB Number

STUDY00001615


Contact
Email
clinicaltrials@cshs.org