The purpose of this study is to determine whether using an injection of adipose allograft matrix into the joint can treat osteoarthritis of the hands and help improve pain and disability, while avoiding surgery. Currently, treatment options include splinting and therapy, which may not produce long-term benefits, and steroid injection, which carries the risk of soft tissue injury or deterioration. Traditional surgical options with trapeziectomy are effective but require longer recovery time. Injection of fat into the joint using one’s own tissue has shown promise as a minimally invasive treatment but still requires harvest of the fat under general anesthesia. Using an office-based procedure with off-the-shelf material allows the procedure to be performed in the clinic, provides decreased recovery time, and avoids the risks of more invasive therapies or general anesthesia. Patients in this study will receive an injection of adipose allograft to the arthritic joint, which will be performed in the office using X-ray guidance. Participants will also be asked to complete questionnaires about their pain and disability. Range of motion and strength will be assessed by the study doctor. Researchers anticipate this approach to be effective at alleviating symptoms while avoiding the risks and cost associated with more invasive surgical procedures.