Simvastatin Treatment to Improve Patient-Reported Outcomes in Chronic Pancreatitis

What is the Purpose of this Study?

The purpose of this pilot study is to evaluate a drug called simvastatin for potential treatment of adults with recurrent acute pancreatitis or chronic pancreatitis. Participants will receive simvastatin or placebo (inactive substance); they will be asked to complete questionnaires, and blood draws. Simvastatin is approved by the U.S. Food and Drug Administration (FDA) to help lower cholesterol, but its use in this study is experimental. Researchers hope that simvastatin will have positive effects in reducing chronic pain associated with chronic pancreatitis and recurrent acute pancreatitis, in addition to improving overall quality of life and outcomes.


Eligibility

  • 1. Provision of signed and dated informed consent form
  • 2. Stated willingness to comply with all study procedures and availability for the duration of the study
  • 3. Male or female, aged 18-75 at time of enrollment
  • 4. Diagnosis of Recurrent Acute or Chronic Pancreatitis not attributable to gallstones (i.e., suspected or definite biliary etiology), medications, trauma or autoimmune pancreatitis. For CP, imaging studies that can be used for diagnosis classification using Cambridge criteria46,47.
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Where can I participate?

Beverly

More about this Clinical Trial

What is the full name of this clinical trial?

Simvastatin treatment to improve patient-reported outcomes in patients with chronic pancreatitis

Study Details
Disease Type/Condition

Other

Principal Investigator

Pandol, Stephen

Age Group

Adult

Phase

I

IRB Number

STUDY00002293

ClinicalTrials.gov ID

NCT05771675

Key Eligibility
ClinicalTrials.gov

How do I learn more about this study?
Email
clinicaltrials@cshs.org
Study Detail
Disease Type/Condition

Other

Principal Investigator

Pandol, Stephen

Age Group

Adult

Phase

I

IRB Number

STUDY00002293

ClinicalTrials.gov ID

NCT05771675

Key Eligibility
ClinicalTrials.gov

Contact
Email
clinicaltrials@cshs.org