What is the Purpose of this Study?

The purpose of this study is to evaluate the effect of an experimental drug called fisetin compared to placebo (inactive substance) on lung function in older adults with a history of smoking. The study uses a short course of fisetin designed to remove aging or damaged cells (called senescent cells). Researchers will also examine certain blood markers that may show how fisetin affects these cells. Fisetin is a “senolytic” drug, which means it selectively targets and eliminates senescent cells. This process helps the body clear out these cells within a short time, which may reduce inflammation and tissue damage. Participants will be randomly assigned to take either fisetin or placebo by mouth. They will also have their lung function tested, provide blood samples, and complete other health assessments. Participants will be adults at least 60 years old with 10+ years of smoking history or adults at least 60 years old who have never smoked.

Eligibility

Where can I participate?