Syn-Sleep Study

What is the Purpose of this Study?

The purpose of the study is to evaluate the use of an experimental test called the Syn-One Test for identifying patients with idiopathic rapid eye movement sleep disorder (iRBD) that will progress to synucleinopathies (a type of neurogenerative disease). Individuals with iRBD have unpleasant dreams and vigorous behavior during sleep that can result in injuries. This condition often is associated with the development of synucleinopathies, such as Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and multiple system atrophy, within 10 to 15 years. Synucleinopathies share the presence of a protein called alpha-synuclein (P-SYN) deposits in the nervous system. P-SYN can be measured in the skin; the Syn-One Test measures P-SYN in skin biopsies. Results of the Syn-One Test alone will not be used to change the participant’s usual healthcare and will be compared against standard methods of testing.


Eligibility

  • 1. Males and females age 18-85
  • 2. Subjects will have repeated episodes of sleep related vocalizations and/or complex motor behaviors
  • 3. Sleep-related behaviors/disturbances must be documented by polysomnography to occur during REM sleep
  • 4. Polysomnographic recording is consistent with REM sleep without atonia
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Where can I participate?

Beverly

More about this Clinical Trial

What is the full name of this clinical trial?

Cutaneous Phosphorylated Alpha-Synuclein for Detection of Prodromal Synucleinopathies

Study Details
Disease Type/Condition

Movement Disorders

Principal Investigator

Tagliati, Michele

Age Group

Adult

Phase

N/A

IRB Number

STUDY00003017

ClinicalTrials.gov ID

NCT05757206

Key Eligibility
ClinicalTrials.gov

How do I learn more about this study?
Email
clinicaltrials@cshs.org
Study Detail
Disease Type/Condition

Movement Disorders

Principal Investigator

Tagliati, Michele

Age Group

Adult

Phase

N/A

IRB Number

SYN-SLEEP

ClinicalTrials.gov ID

NCT05757206

Key Eligibility
ClinicalTrials.gov

Contact
Email
clinicaltrials@cshs.org