Primary Biliary Cholangitis: Volixibat in the Treatment of Cholestatic Pruritus

Summary

The purpose of this study is to determine the effectiveness and safety of an investigational drug called volixibat in treating pruritus (itching) in patients with primary biliary cholangitis (PBC). It is believed that the increased circulation of bile acids in patients with PBC leads to itching. Volixibat is a medicine that lowers circulating bile acid levels, and as a result, is also thought to reduce itching associated with PBC. Study procedures include clinic visits for safety evaluations, questionnaire completions, and blood draws. Researchers also want to measure the biomarkers of PBC disease progression. A biomarker is a biological molecule found in blood and other body fluids or tissues that may be a sign of a condition or disease and can be used to predict response to a specific treatment.


Inclusion Criteria

Not Available


Study Location(s)

Beverly


Full Title

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Volixibat in the treatment of Cholestatic Pruritus in Patients with Primary Biliary Cholangitis

Details
Disease Type/Condition

Other

Principal Investigator

Ayoub, Walid

Age Group

Adult

Phase

II

IRB Number

STUDY00002421


Contact
Email
clinicaltrials@cshs.org
Want to join the study or
learn more?

Details
Disease Type/Condition

Other

Principal Investigator

Ayoub, Walid

Age Group

Adult

Phase

II

IRB Number

VLX-601


Contact
Email
clinicaltrials@cshs.org
Want to join the study or
learn more?