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38 results found


Lymphoid Leukemia

AZD0486 in Adolescents and Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

The purpose of this study is to learn more about an experimental drug called AZD0486 and determine whether it will be safe, tolerable, and effective in treating B-cell acute lymphoblastic leukemia (B-ALL). AZD0486 is ...


Brain and Nervous System, Melanoma, Other Hematopoietic, Soft Tissue

Cobolimab in Combination with Dostarlimab in Pediatric and Young Adult Participants With Newly Diagnosed and Relapsed/Refractory Tumors

The purpose of this study is to evaluate an experimental drug called cobolimab, given with dostarlimab (an anti-cancer medication used in adults) in children, teens, and young adults whose cancer has spread to other parts ...


Other

Ultragenyx_GTX-102-CL301

GTX-102 is a human ubiquitin-protein ligase E3A antisense (UBE3A-AS) transcript-targeted antisense oligonucleotide (ASO) intended for the treatment of Angelman syndrome (AS). Findings from the Phase 1/2 dose-finding study (GTX-102-001) suggest a positive efficacy signal and ...


Other

Nellcor Vs. Masimo Pulse Oximetry Performance Comparison in Newborns

The purpose of this study is to compare heart rate and oxygen saturation performance between 2 pulse oximeters (Nellcor and Masimo, both approved by the U.S. Food and Drug Administration) in newborns. Pulse oximeters are ...


Other

ER004 Post-Intra-Amniotic Treatment in Males With XLHED

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called ER004 in X-linked hypohidrotic ectodermal dysplasia (XLHED) when given before birth (injected into the amniotic fluid that surrounds ...