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378 results found


Valvular Heart Disease

TRISCEND II Pivotal Trial

This study focuses on adults who have tricuspid regurgitation (TR), a condition in which the heart's tricuspid valve does not close tightly, causing blood to flow backwards in the wrong direction. The purpose of the ...


Melanoma

Early Discontinuation of Anti-PD-1 Therapy in Patients With Advanced Melanoma

This study focuses on individuals who have advanced melanoma cancer that is currently being treated with one immunotherapy drug (anti-PD-1 drugs nivolumab or pembrolizumab) or a combination of nivolumab and ipilimumab. Researchers aim to determine ...


Kidney

Immunotherapy-Based Combination Therapy With Or Without Cytoreductive Nephrectomy

This study focuses on individuals who have newly diagnosed kidney cancer that has spread outside of the kidney (metastatic kidney cancer) and who have not started therapy or just recently started their first therapy. Patients ...


Other

Optimizer Smart PAS

The MDAC panel recommended a post-approval study that evaluates data such as cardiac outcomes, quality of life, mortality, and functionality. Long term data are also needed to assess complication rates and potential interactions with other ...


Inflammatory Bowel Disease

CORALE - IBD

This study focuses on individuals who are at least 13 years old and have inflammatory bowel disease (Crohn's disease or ulcerative colitis). The purpose of the study is to understand the effects of COVID-19 vaccination ...