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385 results found


Orthopaedics

Acute Open Reduction Internal Fixation Versus Distal Femur Replacement

This study focuses on individuals who have a distal femur fracture. A distal femur fracture is a condition in which the bone breaks in several pieces above the knee joint, requiring surgery. The purpose of ...


Brain and Nervous System

Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

The purpose of the study is to determine whether an investigational drug called pembrolizumab combined with standard-of-care stereotactic radiation therapy and surgery is safe and effective in patients with recurrent glioblastoma. Researchers will evaluate whether ...


Heart failure

Heart Failure: In-Hospital Initiation of Dapagliflozin in Acute Heart Failure (DAPA ACT HF-TIMI 68)

The purpose of this study is to evaluate whether a drug called dapagliflozin is safe and effective when added to conventional heart failure therapy in patients who have been admitted to the hospital for acute ...


Other

AGENT IDE

To assess the safety and effectiveness of the AgentTM Paclitaxel Coated PTCA Balloon Catheter compared to balloon angioplasty (POBA) in patients with in-stent restenosis (ISR) of a previously treated lesion of up to 26 mm ...


Multiple Sclerosis

Multiple Sclerosis Research Biomarkers

The purpose of this study is to determine whether combining information from visual assessment and blood markers, as well as historical and ongoing magnetic resonance imaging (MRI) of the brain, orbit (the part of the ...