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Sparsentan Treatment in Pediatric Subjects

The purpose of this study is to determine the safety and effectiveness of an investigational drug called sparsentan in the treatment of kidney diseases and whether it is safe to use in children who are ...


Heart Transplant, Heart failure

Heart Transplant, Heart Failure: Evaluating the Safety of Utilizing Donor Hearts from Donation after Circulatory Death (DCD) Donors compared to Donor Hearts from Donation after Brain Death (DBD) Donors (DCD IIT)

The purpose of this study is to evaluate the safety of using hearts from donors after circulatory death (DCD) compared to hearts from donors after brain death (DBD) in individuals who have been listed to ...


Congenital heart

Edwards SAPIEN 3 Transcatheter Pulmonary Valve System with Alterra Adaptive Prestent

The purpose of this study is to evaluate the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Pulmonary Valve System with the Alterra Adaptive Prestent, which is approved by the U.S. Food and Drug ...


Prostate

NRG, NRG-GU010, Ph 3, Open Label, Prostate, RT vs. RT + ADT vs. RT + ADT + Darolutamide

1.1 Primary Objectives: 1.1.1 De-Intensification Study: To determine whether men with National Comprehensive Cancer Network (NCCN) unfavorable intermediate risk (UIR) prostate cancer and lower Decipher genomic risk (Decipher score < 0.40) treated with RT alone instead of ...


ATTR-CM, Cardiac amyloidosis

ATTR CM: Efficacy and Safety of NNC6019-0001 in Transthyretin Amyloid Cardiomyopathy (ATTR CM)

The purpose of this study is to determine whether an investigational drug called NNC6019-0001 can be used to treat people with transthyretin (TTR) amyloid cardiomyopathy, a heart disease due to TTR amyloidosis. Participants will undergo ...