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325 results found


Movement Disorders, Parkinson's Disease

Intravenous Prasinezumab in Early Parkinson's Disease

The purpose of this study is to compare the effects of an experimental drug called prasinezumab in patients with early Parkinson's disease who are taking standard medication (either rasagiline, selegiline, or levodopa) to manage their ...


Valvular Heart Disease

CSTN: PRIMARY

The purpose of this study is to compare the risks and benefits of two procedures used to help patients with mitral valve regurgitation (MR). MR is a condition in which the heart valve does not ...


Brain and Nervous System

Identification of Pre-Malignant Lesions In Pediatric Patients With Neurofibromatosis Type 1

The purpose of this study is to evaluate the use of a magnetic resonance imaging (MRI) technique called whole-body MRI, combined with a computer program, in children and adolescents (5-18 years old) with neurofibromatosis type ...


Pulmonary Vascular Disease

HI-PEITHO

This study focuses on individuals who have been diagnosed with pulmonary embolism (having a blood clot in one or both of the lungs). The purpose of the study is to investigate whether treatment with anticoagulation ...


ATTR-CM, Cardiac Amyloidosis

AG10-304

The purpose of this study is to evaluate the safety and effectiveness of an investigational drug called acoramidis (AG10) for the treatment of a rare disease called symptomatic transthyretin amyloid cardiomyopathy (ATTR-CM). ATTR-CM occurs when ...