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387 results found


Melanoma

Sarilumab Combined With Ipilimumab, Nivolumab, and Relatlimab in Advanced/Unresectable Melanoma

This study will evaluate the safety and tolerability of a drug called sarilumab in combination with ipilimumab, nivolumab, and relatlimab in advanced/unresectable melanoma (melanoma that cannot be removed by surgery). Ipilimumab, nivolumab, and relatlimab ...


Other

Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

This study compares 2 methods of treating infants who were born prematurely with a patent ductus arteriosus (PDA). A PDA is a blood vessel connecting the lungs and the heart. All infants have a PDA ...


Prostate

Apalutamide With Carotuximab in Metastatic, Castration-Resistant Prostate Cancer

This study will evaluate an experimental drug called carotuximab when taken in combination with apalutamide, in comparison to apalutamide alone, for the treatment of metastatic, castration-resistant prostate cancer. Carotuximab is a genetically engineered antibody (type ...


Other

MYK-224 in Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

The purpose of this study is to examine the safety and effectiveness of an investigational drug called MYK-224 in individuals with obstructive hypertrophic cardiomyopathy (oHCM). The amount of MYK-224 that reaches the blood stream and ...


Lung

Open vs. Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

The purpose of this study is to compare the effects of 2 surgery methods for people with bone cancer (osteosarcoma- OST) that has spread to the lung. The 2 types of surgeries are called open ...