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Coronary Sinus Reducer in Refractory Angina II (COSIRA-II)

The purpose of this study is to collect information on the safety and effectiveness of an investigational device called the Reducer for treatment of patients with refractory (persistent) angina. Angina is a type of chest ...


Ulcerative colitis

Guselkumab and Golimumab in Ulcerative Colitis

The purpose of this study is to determine whether the experimental combination of guselkumab and golimumab is safe and effective for treating patients with moderately to severely active ulcerative colitis. Treatment with three different doses ...


Other

Aficamten Compared to Metoprolol in Symptomatic Obstructive Hypertophic Cardiomyopathy

The purpose of this study is to compare the effectiveness and potential side effects of an investigational drug called aficamten with the beta-blocker, metoprolol, in people with obstructive hypertrophic cardiomyopathy (oHCM). Obstructive HCM is a ...


Heart transplant candidates

Development of Non-Invasive Cell-Free DNA to Supplant Invasive Biopsy in Heart Transplantation

This study focuses on adults who are undergoing heart transplant evaluation or are on the waiting list and expected to receive a heart transplant. The purpose of the study is to determine whether an investigational ...


Breast cancer

Ivermectin and Balstilimab in Metastatic Triple Negative Breast Cancer

The purpose of this study is to evaluate whether concurrent use of oral ivermectin and intravenous (IV) balstilimab is safe and effective in treating patients with triple negative breast cancer. Researchers want to know the ...