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325 results found


Lung

HPN328 in Advanced Cancers Associated with DLL3

The purpose of this study is to test the safety and effects of an experimental drug called HPN328 alone and in combination with another drug, atezolizumab, in patients who have small cell lung cancer or ...


Breast

Shorter Anthracycline-Free Chemo Immunotherapy in Early Triple-Negative Breast Cancer

The purpose of this study is to compare the standard-of-care chemo-immunotherapy (carboplatin/paclitaxel followed by adriamycin/cyclophosphamide plus pembrolizumab, given in 6 months) treatment for early-stage, triple-negative breast cancer to a shorter non-anthracycline chemo-immunotherapy treatment (carboplatin docetaxel ...


Other

Eplontersen in Transthyretin-Mediated Amyloid Cardiomyopathy

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called eplontersen in people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). ATTRCM is a disease caused by change in a protein ...


Other

Outcomes of Children Newly Diagnosed with Crohn’s Disease

The purpose of this study is to determine the reasons why some children with newly diagnosed Crohn’s disease (CD) heal their bowel inflammation after one type of therapy and why others do not. CD is ...


Breast, Cervix, Colon, Esophagus, Kidney, Liver, Lung, Melanoma, Other Female ...

GIM-122 as a Single Agent in Advanced Solid Malignancies

The purpose of this study is to evaluate an investigational drug called GIM-122 in people who have been diagnosed with an advanced or malignant tumors. These patients have tumors that were eligible to be treated ...