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437 results found


Colon, Lung, Melanoma, Other Female Genital, Thyroid, Unknown Sites

KIN-2787 in Participants With BRAF and/or NRAS Mutation-Positive Solid Tumors

This early-phase clinical trial is designed for adults with advanced solid tumors that have spread (metastasized) and carry specific genetic mutations in the BRAF and/or NRAS genes—both of which are known to drive cancer progression. ...


Lip, Oral Cavity and Pharynx

Using Circulating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-Associated Oropharyngeal Cancer

The purpose of this study is to determine whether using less intense radiation therapy and chemotherapy (chemoradiation) after trans-oral robotic surgery (TORS) will be as effective in treating HPV-associated oropharyngeal cancer as standard treatment while ...


Other

J-Valve to Treat Aortic Regurgitation via Transcatheter Therapy

The purpose of this study is to learn about the safety and performance of an experimental device called the J-Valve TF System. The device is designed to treat severe aortic regurgitation, (AR). AR occurs when ...


Thoracic Cancers

Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography

The purpose of this study is to determine whether an imaging scan called a Sodium Fluoride Cardiac PET/MRI (18F-NaF PET/MRI) can detect early injury to heart blood vessels (coronary arteries) in patients with stage II-IV ...


Breast

MammaPrint, BluePrint, and Full-Genome Data Linked With Clinical Data to Evaluate New Gene Expression Profiles: An Adaptable Registry (FLEX)

The purpose of this study is to create a large-scale, population-based database that will match health information with genome (DNA) data to potentially identify new gene associations in breast cancer. The study focuses on patients ...