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Vedolizumab Dual Targeted Therapy with Tofacitinib in Ulcerative Colitis

The purpose of this study is to determine whether combining medications for ulcerative colitis (vedolizumab with tofacitinib) is safe and improves symptoms of the disease. This treatment combination is referred to as “dual targeted therapy” ...


Other

K-808 (Pemafibrate) in Primary Biliary Cholangitis

The purpose of this study is to determine the safety and effectiveness of an experimental drug called K-808 in participants with primary biliary cholangitis (PBC). K-808 (also called K-877-ER or pemafibrate) is designed to slow ...


Other

Hepatocyte Transplantation Into Periduodenal Lymph Nodes in End-Stage Liver Disease

The purpose of this study is to evaluate an experimental treatment called allogeneic hepatocyte transplantation (injection of donor liver cells) as a possible treatment for end-stage liver disease (ESLD). The study aims to identify the ...


Other

Lorundrostat in Uncontrolled Hypertension

This study focuses on individuals who have high blood pressure that is not well-controlled with their current medications (also known as uncontrolled hypertension) and who have received an experimental drug called MLS-101 or lorundrostat in ...


Prostate

High Five Trial: High-Risk Prostate Cancer

The purpose of this study is to compare 2 radiation schedules that can be used to treat patients with high-risk prostate cancer. One approach delivers a higher dose of radiation per treatment and uses fewer ...