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394 results found


Obesity

Evaluating Environmental Control (AVOID) and Inhibitory Control (RESIST) Strategies to Improve Weight Management Outcomes

This study tests strategies to help adults with overweight or obesity (BMI between 25-45 kg/m2) “stick” to weight management recommendations. Specifically, the study evaluates the benefit of 2 self-regulatory approaches to improve intentional weight loss ...


Melanoma

Cemiplimab plus Ziv-Aflibercept in Metastatic Uveal Melanoma

The purpose of this phase II study for advanced melanoma is to evaluate the safety (side effects profile) and effectiveness (tumor shrinkage) of cemiplimab and ziv-aflibercept, when given together. Cemiplimab is an anti-cancer drug called ...


Melanoma

Fianlimab, Cemiplimab, and Ipilimumab in Anti-PD-1 Refractory Melanoma

The purpose of this study is to determine whether the drug combination of fianlimab, cemiplimab, and ipilimumab is a safe and effective treatment for refractory melanoma. The study focuses on people whose melanoma has spread ...


Breast

Ivonescimab in Combination With Carboplatin + Docetaxel in Early Stage Triple Negative Breast Cancer

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called ivonescimab when combined with standard chemotherapy (carboplatin and docetaxel) before surgery for the treatment of early stage, triple-negative ...


Other

Vutrisiran in Patients With Transthyretin Amyloidosis with Cardiomyopathy

The purpose of this study is to evaluate the safety of a drug called vutrisiran (amvuttra) and determine the effects it has on people with transthyretin amyloidosis (ATTR) with cardiomyopathy (either hereditary or wild type). ...