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Oral Metformin Versus Injectable Insulin for the Treatment of Gestational Diabetes

Gestational diabetes mellitus (GDM) is one of the most widespread medical problems in pregnancy. The most common medication is insulin, which requires daily injections; another option is metformin, which is an oral pill. The purpose ...


Prostate

Epigenetic Therapy Before Prostatectomy in Men With Prostate Cancer

This study focuses on people who have prostate cancer and are planning to have a radical prostatectomy (removal of prostate and some surrounding tissue). The purpose of the study is to assess the safety, tolerability, ...


Breast

PF-07220060 in Combination With Letrozole in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

This study focuses on people who have hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer and have not received any systemic anti-cancer treatment for their disease. The ...


Other

Quantification of Phosphorylated Alpha-Synuclein in Parkinson’s Disease and REM Sleep Behavior Disorder

The purpose of this study is to assess the ability of the Syn-One Test to measure the amount of phosphorylated alpha-synuclein (P-SYN) in skin biopsies from patients with Parkinson’s disease (PD) or rapid eye movement ...


Other Female Genital

Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Endometrial Cancer

The purpose of this study is to learn whether an experimental drug called sacituzumab govitecan (also called SG or Trodelvy) can help patients with endometrial cancer that has spread or recurred to live longer compared ...