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Neoadjuvant Immunotherapy With Response-Adapted Treatment in Resectable Stage III/IV Cutaneous Squamous Cell Carcinoma

This study focuses on people who have advanced squamous cell skin cancer that can be removed with surgery. The purpose of the study is to determine whether giving an immunotherapy drug called cemiplimab before and ...


Other

Using Circulating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-Associated Oropharyngeal Cancer

The purpose of this study is to determine whether using less intense radiation therapy and chemotherapy (chemoradiation) after trans-oral robotic surgery (TORS) will be as effective in treating HPV-associated oropharyngeal cancer as standard treatment while ...


Other

J-Valve to Treat Aortic Regurgitation via Transcatheter Therapy

The purpose of this study is to learn about the safety and performance of an experimental device called the J-Valve TF System. The device is designed to treat severe aortic regurgitation, (AR). AR occurs when ...


Breast

Defining Lipidomic and Immune Signatures of Aromatase Inhibitor-Associated Musculoskeletal Symptoms

The purpose of this study is to examine biological molecules in the blood that may predict the onset and severity of aromatase inhibitor-associated musculoskeletal symptoms (AIMSS). AIMSS is a condition that affects some patients who ...


Thoracic Cancers

Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography

The purpose of this study is to determine whether an imaging scan called a Sodium Fluoride Cardiac PET/MRI (18F-NaF PET/MRI) can detect early injury to heart blood vessels (coronary arteries) in patients with stage II-IV ...