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366 results found

Colon, Lung, Melanoma, Other Female Genital, Thyroid, Unknown Sites

Pierre Fabre Médicament, KN-8701/KIN2787CI101, Ph1/1b, open label, Solid Tumors, KIN-2787

2. Study Objectives 2.1. Part A Dose Escalation 2.1.1. Part A1: KIN-2787 Monotherapy Dose Escalation -The primary objectives of Part A1 are to determine the safety and tolerability of PO administration of KIN-2787 including DLTs in ...

Unknown Sites

Neoadjuvant Immunotherapy With Response-Adapted Treatment in Resectable Stage III/IV Cutaneous Squamous Cell Carcinoma

This study focuses on people who have advanced squamous cell skin cancer that can be removed with surgery. The purpose of the study is to determine whether giving an immunotherapy drug called cemiplimab before and ...

Other

Using Circulating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-Associated Oropharyngeal Cancer

The purpose of this study is to determine whether using less intense radiation therapy and chemotherapy (chemoradiation) after trans-oral robotic surgery (TORS) will be as effective in treating HPV-associated oropharyngeal cancer as standard treatment while ...

Breast

AIMSS; Lipidomic; Aromatase Inhibitor Associated Musculoskeletal

The purpose of the study is to identify circulating biomarkers associated with new or worsening joint stiffness and pain consistent with AIMSS in patients initiating AI therapy for the treatment of their breast cancer. ...

Unknown Sites

CSMC,IIT2023-08-ATKINS-ACCEL-RT, open, pilot, any histology/metastatic malignancy, ATHERO-RT

Primary Objective: To determine the feasibility of using 18F-NaF PET/MRI imaging for detection of real-time atherosclerosis activity in patients at high risk of RT-associated cardiac dysfunction. Secondary Objectives: To measure changes in standard uptake value (SUV) and coronary ...