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Ivonescimab Combined With Chemotherapy Versus Pembrolizumab Combined With Chemotherapy in Metastatic Non-Small Cell Lung Cancer

This study focuses on people with newly diagnosed squamous or non-squamous, non-small cell lung cancer that has spread to other areas of the body. The purpose of the study is to evaluate the effectiveness and ...

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GSK4532990 for Steatohepatitis in Adults With Alcohol-related Liver Disease

The purpose of this study is to evaluate the safety and effects of an experimental drug called GSK4532990 on steatohepatitis (fatty liver disease) in adults with alcohol-related liver disease (ALD), a condition in which there ...

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ARTIA Reconstructive Tissue Matrix in Implant-Based Two-Stage Prepectoral Breast Reconstruction Post-Mastectomy

The purpose of this study is to evaluate the safety and effectiveness of an experimental product called the ARTIA Reconstructive Tissue Matrix when used in immediate, implant-based, two-stage breast reconstruction following mastectomy for cancer treatment ...

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p19 Inhibition of the IL-23 Pathway to Establish Efficacy in Pediatric Crohn’s Disease

The purpose of this study is to determine whether the experimental drugs guselkumab and mirikizumab work in patients with moderate to severe Crohn’s disease (CD) who are 2 to 17 years old and have not ...

Colon, Other Digestive Organ, Pancreas, Rectum

A Platform Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

This study focuses on people who have either advanced colorectal cancer or advanced pancreatic cancer that is driven by a gene known as RAS. The purpose of the study is to evaluate the safety of ...