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Leveraging Immunotherapy For Tumor Downstaging to Milan Criteria in Hepatocellular Carcinoma

The purpose of this study is to learn whether combining immunotherapy with a liver-directed tumor procedure can safely and effectively shrink or control liver cancer (also called hepatocellular carcinoma or HCC) in people whose cancer ...


Breast, Cervix, Lung, Other Female Genital, Ovary

SNV4818 as Monotherapy or in Combination With Other Anticancer Agents

The purpose of this study is to evaluate different drug doses of an experimental drug called SNV4818 and identify safe levels in patients with an advanced cancer that has a mutation (change) in their PIK3CA ...


Other

SafeHeal Colovac Anastomosis Protection Device Evaluation Pivotal Study

The purpose of this study is to evaluate the safety and effectiveness of the Colovac device in patients undergoing colon cancer removal surgery that preserves the sphincter (muscle that relaxes or tightens to open or ...


Other

Ongoing Lung Decline With Age Intensified Response

The purpose of this study is to evaluate the effect of an experimental drug called fisetin compared to placebo (inactive substance) on lung function in older adults with a history of smoking. The study uses ...


Anus, Colon, Lung, Pancreas, Rectum

BBO-11818 in Advanced KRAS Mutant Cancers

This study focuses on people who have advanced non-small cell lung cancer, colorectal cancer, pancreatic ductal adenocarcinoma, or other solid tumor with a specific KRAS mutation (change in the KRAS gene that plays a part ...