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Danicamtiv in Symptomatic Genetic and Familial Dilated Cardiomyopathy

The purpose of this study is to evaluate whether an experimental drug called danicamtiv improves heart function in adults with dilated cardiomyopathy compared to current standard treatment. DCM is a condition in which the heart ...


Anus, Breast, Cervix, Colon, Esophagus, Lip, Oral Cavity and Pharynx ...

DB-1311 in Combination With BNT327 or DB1305 in Advanced/Metastatic Solid Tumors

The purpose of this study is to evaluate the safety and tolerability of 2 experimental drug combinations in people who have been diagnosed with an advanced/metastatic (cancer that has spread from where it started) solid ...


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The Global Paradise System US Post Approval Study

The purpose of this study is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System in patients who are unable to lower their blood pressure with lifestyle changes and medication. The Paradise ...


Other

Investigation of a Novel, Magnetically Levitated VAD for Refractory Left Ventricular Heart Failure (INNOVATE Trial)

The purpose of this study is to evaluate the safety and effectiveness of an experimental device called the BrioVAD System compared to the commercially available HeartMate 3 LVAS. Both the BrioVAD System and HeartMate 3 ...


Other

MVX-220 Gene Therapy Administered by Intra-Cisterna Magna Injection to Participants With Angelman Syndrome

The purpose of this study is to learn about the safety of an experimental gene therapy called MVX-220 as a potential treatment for Angelman syndrome (AS). AS is caused by changes (mutations) affecting the UBE3A ...