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Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

This study focuses on people who have been diagnosed with heart failure (a condition in which the heart muscle is unable to pump enough blood to the body), have left bundle branch block (LBBB, a ...


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Transition Regimens to KPL-387 Monotherapy from Standard Therapies in Recurrent Pericarditis

The purpose of this study is to evaluate the effectiveness of an experimental drug called KPL-387 in people who are currently taking medications for the treatment of recurrent pericarditis (RP) and whose pericarditis symptoms are ...


Anus, Bones and Joints, Brain and Nervous System, Breast, Cervix ...

S241656 as Monotherapy and in Combination With Other Anti-Cancer Therapies

The purpose of this study is to evaluate an experimental drug called S241656 in people who have cancer with a mutation in the KRAS, NRAS, HRAS, BRAF, and/or CRAF (RAF1) genes in their tumor. S241656 ...


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Enhancing Heart Allograft Function With the OCF Heart System

The purpose of this study is to evaluate whether an organ care system (OCS) solution with an added OCS functional enhancer (OFE) and new gas mixture can preserve donor hearts more safely and effectively than ...


Other

Pulsed Field Ablation of Pulmonary Veins Plus Extra-PV Sources in Persistent Atrial Fibrillation Patients, "OPTIMIZE"

The purpose of the OPTIMIZE study is to learn more about the safety and effectiveness of the FARAPULSE Pulsed Field Ablation System, OptiMap Catheter, and OptiMap System in treating persistent atrial fibrillation (AFib), a condition ...