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414 results found


Brain Injury

BOOST-3 NINDS Brain Oxygen Optimization

This study focuses on patients with severe traumatic brain injury (TBI). The purpose of the study is to compare two ways of treating patients with brain injury. Participants will be randomly assigned to one of ...


Certain infectious and parasitic diseases, Multiple Myeloma, Non-Hodgkin Lymphoma

The Coronavirus Risk Associations and Longitudinal Evaluation Study

This study seeks to determine the sociodemographic, clinical, lifestyle/environmental, and molecular determinant of risks and outcomes including but not restricted to following groups of people: (1) patients with confirmed/suspected or possible SARS-CoV-2 exposure/COVID-19 infection, (2) ...


Brain Injury

ICECAP

Brain injury causing coma after cardiac arrest can be fatal or may prevent patients from recovering. This study focuses on comatose, adult survivors of out-of-hospital cardiac arrest that have already been rapidly cooled per standard ...


ATTR-CM, Cardiac amyloidosis

Cardiac Amyloidosis: Strategy to Improve Patient Outcomes by Silencing TTR Formation in ATTR-CM (TTRansform)

- To evaluate the effect of treatment with ION-682884 compared to placebo for 120 weeks on the composite endpoint of cardiovascular (CV) mortality and frequency of CV clinical events in patients with ATTR-CM receiving available ...


Amyotrophic lateral sclerosis (ALS)

The HEALEY ALS Platform Trial

The purpose of the HEALEY ALS Platform Trial is to evaluate the safety and effectiveness of multiple treatments for amyotrophic lateral sclerosis (ALS). A regimen is a specific course of treatment, each with a different ...