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140 results found

Bladder cancer, Ovarian cancer, Uterine cancer

Acrivon Ther, ACR-368-201/GOG-3082,Ph1b/2,Open-label,Ovarian/endometrial/uroth,ACR-368+/-Gemcitabine

Primary Arm 1 Assess the anti-tumor activity of ACR-368 monotherapy in each cohort (ovarian, endometrial, urothelial) of OncoSignature Positive subjects. Arm 2 Assess the safety and tolerability of ACR-368 in combination with LDG Determine the RP2D of LDG Secondary Arm 1 Confirmation of ...

Lung

Non-Small Cell Lung Cancer: Lung-MAP Sub-Study

The purpose of this study is to determine whether a combination of drugs (capmatinib, osimertinib, and ramucirumab) is beneficial compared to another combination (capmatinib and osimertinib) for treating non-small cell lung cancer tumors that have ...

Ovary

Comparing the Non-Inferiority of Salpingectomy to Salpingo-Oophorectomy to Reduce the Risk of Ovarian Cancer

This study aims to determine whether 2 surgical procedures are no different for ovarian cancer risk reduction in individuals with BRCA1 mutations who have completed childbearing. (Mutations in the BRCA1 gene are associated with a ...

Brain and Nervous System

SMO/AKT/NF2/CDK Inhibitors in Progressive Meningiomas

This study aims to determine whether tumor genetic testing would be helpful in guiding treatment for patients with a meningioma that has gotten bigger or grown back after treatment. Meningiomas are tumors that grow on ...

Multiple Myeloma

Low-Dose Palliative Radiotherapy in Bone Metastases from Multiple Myeloma

The purpose of this study is to evaluate whether pain relief can be achieved using only 1-2 radiation treatments to a painful bone lesion in patients with multiple myeloma (MM). Bone disease is common in ...