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142 results found


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Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers

The purpose of this study is to evaluate how the combination of the drugs nivolumab and relatlimab might work in people with advanced cancer that is “microsatellite instability high” (MSI-H). Microsatellite instability is a marker ...


Myeloid and Monocytic Leukemia

MYELOMATCH, Master Screening and Reassessment Protocol

In this study, researchers will plan various treatment substudies for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who have not yet started treatment. Participants will be asked to undergo testing on their ...


Unknown Sites

Dinutuximab Added to Intensive Multimodal Therapy for Children with Neuroblastoma

The purpose of this study is to compare the outcomes of a drug called dinutuximab, given early with induction therapy, to the effects of standard induction therapy with the addition of dinutuximab later in therapy, ...


Cervix, Kidney, Lung, Other Female Genital, Pancreas, Rectum, Small Intestine

KO-2806 in Adult Patients With Advanced Solid Tumors

The purpose of this study is to determine the highest tolerable dose of an investigational drug called KO-2806 in combination with an approved therapy called cabozantinib, in people with renal cell carcinoma (RCC) of predominantly ...


Unknown Sites

Newly Diagnosed Very Low-risk and Low-Risk Fusion Negative Rhabdomyosarcoma

This study focuses on people who have been diagnosed with rhabdomyosarcoma (RMS), a type of cancer that occurs in the soft tissues of the body and whose cancer is considered low-risk (LR-RMS). The purpose of ...