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157 results found


Colon, Liver, Lung, Other Digestive Organ, Other Female Genital, Pancreas ...

VS-7375 in Advanced KRAS G12D-Mutant Solid Tumors

This study focuses on people who have been diagnosed with a solid tumor that contains a specific change (mutation) in the KRAS gene. One common mutation in KRAS is called G12D; participants in this study ...


Unknown Sites

Zanzalintinib vs Everolimus in Locally Advanced or Metastatic Neuroendocrine Tumors

The purpose of this study is to evaluate the effectiveness of an experimental drug called zanzalintinib compared to the standard-of-care treatment, everolimus, in treating people with locally advanced or metastatic neuroendocrine tumors. Zanzalintinib is a ...


Breast

RLY-2608 + Fulvestrant Versus Capivasertib + Fulvestrant as Treatment for HR+/HER2- Metastatic Breast Cancer

This study focuses on people who have metastatic (spread to other areas of the body) hormone receptor-positive, human epidermal growth factor 2-negative (HR+/HER2-) breast cancer that has a mutation in a gene called PIK3CA. The ...


Anus, Breast, Colon, Liver, Lung, Pancreas, Prostate, Rectum

Phase I Study of DB-1317 in Selected Advanced/Metastatic Solid Tumors

The purpose of this Phase 1 study is to assess the safety and tolerability of an experimental drug called DB-1317 in patients with an advanced/metastatic (cancer that has spread from its original site) solid tumor ...


Anus, Breast, Cervix, Colon, Esophagus, Lip, Oral Cavity and Pharynx ...

DB-1311 in Combination With BNT327 or DB1305 in Advanced/Metastatic Solid Tumors

The purpose of this study is to evaluate the safety and tolerability of 2 experimental drug combinations in people who have been diagnosed with an advanced/metastatic (cancer that has spread from where it started) solid ...