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163 results found


Breast, Larynx, Lung, Other Urinary

AVZO-1418 in Locally Advanced or Metastatic Solid Tumors

The purpose of this study is to evaluate the safety and tolerability of an experimental drug called AVZO-1418 for the treatment of locally advanced solid tumors (cancers that have grown to a serious stage and ...


Breast, Colon, Esophagus, Kidney, Liver, Lung, Melanoma, Other Female Genital ...

Nenocorilant in Combination With Anti-Programmed Cell Death/(Ligand) 1 in Solid Tumors

When cancers develop resistance to immunotherapy, tumors subsequently begin to grow. Cancer may use cortisol, a steroid hormone naturally produced in the body, to develop resistance to immunotherapy. Nenocorilant blocks the action of cortisol ...


Melanoma

Community-Based Strategies for Early Detection of Melanoma

The purpose of this study is to evaluate whether community education and digital skin screening tools can help improve early detection of melanoma when it is most treatable. Eligible participants may include melanoma survivors or ...


Colon, Rectum

Ivonescimab With FOLFOX Versus Bevacizumab With FOLFOX in Metastatic Colorectal Cancer

This study focuses on people with metastatic colorectal cancer. The purpose of the study is to evaluate the safety and effectiveness of an experimental drug called ivonescimab/SMT112 in combination with chemotherapy drugs (FOLFOX- oxaliplatin, leucovorin, ...


Lung

HLX43 (Anti-PD-L1 ADC) in Advanced Non-Small Cell Lung Cancer

The purpose of this study is to determine the safety and effectiveness of an experimental drug called HLX43 for the treatment of advanced non-small cell lung cancer (NSCLC). Study procedures include administration of HLX43, questionnaires, ...