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163 results found


Breast

Elacestrant Versus Standard Endocrine Therapy in Early Breast Cancer With High Risk of Recurrence

The purpose of this study is to compare elacestrant with standard endocrine therapy in people with node-positive, estrogen receptor-positive (ER+), HER2-negative early breast cancer who are considered to have a high risk of recurrence. Participants ...


Breast

Zanidatamab With Chemotherapy Compared to Trastuzumab With Chemotherapy in Metastatic HER2-Positive Breast Cancer

This study focuses on people with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (mBC). mBC is a type of breast cancer that has spread (metastasized) to other organs in the body. The ...


Multiple Myeloma

Etentamig and Daratumumab Compared to Daratumumab, Lenalidomide, and Dexamethasone in Multiple Myeloma

The purpose of this study is to evaluate the safety of a drug called etentamig and identify the optimal dose of the drug when combined with another drug, daratumumab, in people with newly diagnosed multiple ...


Unknown Sites

Xaluritamig in Relapsed or Refractory Ewing Sarcoma

The purpose of this study is to learn more about how treatment with an experimental drug called xaluritamig works in children, adolescents and young adults with Ewing sarcoma (EWS) that has come back after treatment ...


Brain and Nervous System

Silevertinib in Combination With Temozolomide in Newly Diagnosed Glioblastoma

The purpose of this study is to determine whether combining an experimental drug called silevertinib with temozolomide (a standard treatment) after surgery and radiotherapy helps treat cancer better than using temozolomide alone in people with ...