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150 results found


Breast

Durvalumab Plus Chemotherapy Versus Chemotherapy Alone in HR Positive / HER2 Negative Stage II-III Breast Cancer

This study focuses on individuals who have early-stage breast cancer that is hormone receptor (HR)-positive and human epidermal growth factor receptor (HER2)-negative with high risk of cancer recurrence based on MammaPrint testing (test that analyzes ...


Eye and Orbit, Melanoma

IDE196 in Combination with Crizotinib in Metastatic Uveal Melanoma

The purpose of this study is to determine whether an experimental medication, IDE196 (also called darovasertib), in combination with another drug, crizotinib, is safe and effective in people who have cancer in their eye (uveal ...


Breast

Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Breast Cancer

The purpose of this study is to determine whether the addition of chemotherapy to hormonal therapy and ovarian suppression is more effective than the usual approach of hormonal therapy and ovarian suppression alone for treatment ...


Colon, Melanoma, Other Female Genital, Rectum

ASP1012 in Locally Advanced or Metastatic Solid Tumors

The goal of this study is to determine at what dose an experimental drug called ASP1012 is tolerated in people with locally advanced (spread to nearby areas) or metastatic (spread to distant parts) solid tumors ...


Breast

TAD/SNB in T1-2N0 ER+ Her2- Breast Cancer With Ultrasound-Detected Nodal

This study focuses on women who have estrogen receptor-positive breast cancer with axillary nodal disease (cancer that has spread to a lymph node). The purpose of the study is to determine the safety and effectiveness ...