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161 results found

Breast cancer

De-Escalation of Therapy in Early-Stage TNBC

This study focuses on patients who have been diagnosed with early-stage, triple-negative breast cancer (TNBC) and have recently completed preoperative chemotherapy in combination with the immunotherapy drug pembrolizumab, followed by breast surgery. The purpose of ...


Fasting-Mimicking Diet to Improve Prostate Cancer Control and Metabolic Outcomes

The purpose of this study is to evaluate how a fasting-mimicking diet versus a usual diet influences cancer treatment of metastatic castrate-sensitive prostate adenocarcinoma. The fasting-mimicking diet is a 5-day program of plant-based products that ...


Non-Small Cell Lung Cancer: Lung-MAP Sub-Study

The purpose of this study is to determine whether a combination of drugs (capmatinib, osimertinib, and ramucirumab) is beneficial compared to another combination (capmatinib and osimertinib) for treating non-small cell lung cancer tumors that have ...


Comparing the Non-Inferiority of Salpingectomy to Salpingo-Oophorectomy to Reduce the Risk of Ovarian Cancer

This study aims to determine whether 2 surgical procedures are no different for ovarian cancer risk reduction in individuals with BRCA1 mutations who have completed childbearing. Researchers will compare the removal of fallopian tubes to ...

Brain and Nervous System

Alliance, A071401,Ph 2,Open-label,meningiomas w/SMO/AKT/NF2/CDKmutations, SMO/AKT/NK2/CDK inhibitors

Primary objectives 1 To determine the activity of a SMO inhibitor in patients with meningiomas harboring SMO and PTCH1 mutations as measured by 6-month PFS and response rate. 2 To determine the activity of a FAK inhibitor ...