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155 results found


Brain and Nervous System

Primary CNS Lymphoma: Phase I Trial of Methotrexate, Rituximab, Lenalidomide, and Nivolumab

The purpose of this study is to determine whether the drugs rituximab, methotrexate, lenalidomide, and nivolumab can be safely combined for treatment of primary CNS lymphoma. Researchers also want to learn which dose is the ...


Lung Cancer, Non-small cell

Osimertinib and Carotuximab in Advanced, EGFR-Mutated Non-Small Cell Lung Cancer

The purpose of this study is to examine the safety and effectiveness of an experimental combination therapy of osimertinib (standard drug) with carotuximab (investigational study drug) in patients who are diagnosed with EGFR-mutated, non-small cell ...


Leukemia, other

Inotuzumab Ozogamicin in Children and Young Adults With Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia

This study focuses on children and young adults who have been diagnosed with B-acute lymphoblastic leukemia (B-ALL) that is either unresponsive to therapy (refractory) or has come back after treatment (relapsed). B-ALL is a cancer ...


Colon, Rectum

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

This study focuses on individuals who have colon cancer that has been treated with surgery but has spread to some of their lymph nodes (stage III colon cancer), or who have stage II or stage ...


Lung Cancer, Non-small cell

IOV-4001 in Melanoma or Non-Small-Cell Lung Cancer

The purpose of this study is to determine whether an investigational drug called IOV-4001 is safe and beneficial in the treatment of patients with unresectable or metastatic melanoma or advanced non-small cell lung cancer (NSCLC). ...