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142 results found


Brain Tumors

Fluorescence Detection of Adult Primary Central Nervous System Tumors

This study focuses on individuals who have a primary central nervous system (CNS) tumor and are planning to undergo surgery to remove the tumor. The purpose of the study is to examine the investigational use ...


Lung

SWOG, S1900E, PH II, Open label, prev tx st4 / recurr KRAS G12C NSCLC, AMG 510

Primary To evaluate the response rate (confirmed, complete or partial) of AMG 510 in participants with KRASG12C mutated Stage IV or recurrent non-squamous non-small cell lung cancer (NSCLC). The response rates will be evaluated separately ...


Other Endocrine System, Pancreas

Merck, MK-6482-015, Ph 2, Open-label, PPGL & pNET, MK6482 Monotherapy

The purpose of this study is to evaluate the investigational use of a drug called belzutifan (MK-6482) in people with certain types of pheochromocytoma/ paraganglioma (PPGL) and pancreatic neuroendocrine tumors (pNET). The study will examine ...


Melanoma

ALKS 4230 as Monotherapy in Advanced Melanoma

The purpose of this study is to evaluate the effectiveness, safety, and tolerability of an experimental drug called nemvaleukin (modified interleukin-2, improves immune function towards melanoma) in people with melanoma. The study focuses on individuals ...


Brain and Nervous System

Identification of Pre-Malignant Lesions In Pediatric Patients With Neurofibromatosis Type 1

The purpose of this study is to evaluate the use of a magnetic resonance imaging (MRI) technique called whole-body MRI, combined with a computer program, in children and adolescents (5-18 years old) with neurofibromatosis type ...