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32 results found


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Phase II Study of Unresectable Hepatocellular Carcinoma and Cirrhosis

The purpose of this study is to evaluate the effects of combined immunotherapy regimens (atezolizumab with bevacizumab) in patients with inoperable liver cancer and liver disease (cirrhosis). Participants may receive atezolizumab alone (if they are ...


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MK-7240 in Moderately to Severely Active Ulcerative Colitis

The purpose of this research is to evaluate the safety and effectiveness of an experimental drug called MK-7240 (tulisokibart) compared with placebo (inactive substance) in people with moderately to severely active ulcerative colitis. There are ...


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Tulisokibart in Moderately to Severely Active Crohn's Disease

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called tulisokibart (MK-7240) in people with moderately to severely active Crohn’s disease that has not responded well to treatment. ...


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Etrasimod’s Effects on Vascular Pathobiology Using IUS: A Potential Marker of Early Response in Ulcerative Colitis

This study focuses on people with ulcerative colitis (an inflammatory disease of the bowel) who are starting a drug called etrasimod as standard of care. The study aims to show that etrasimod reduces abnormal blood ...


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Seladelpar in Primary Biliary Cholangitis and Compensated Cirrhosis

The purpose of this study is to determine whether an experimental drug called seladelpar is effective in improving outcomes for people with primary biliary cholangitis (PBC) and compensated cirrhosis. PBC is a chronic liver disease ...