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69 results found


ATTR-CM, Cardiac amyloidosis

Cardiac Amyloidosis: Strategy to Improve Patient Outcomes by Silencing TTR Formation in ATTR-CM (TTRansform)

- To evaluate the effect of treatment with ION-682884 compared to placebo for 120 weeks on the composite endpoint of cardiovascular (CV) mortality and frequency of CV clinical events in patients with ATTR-CM receiving available ...


Women's Heart Disease

Myocardial Steatosis in Women With Coronary Microvascular Dysfunction

This study focuses on women with angina (chest pain) who have been diagnosed with coronary microvascular dysfunction (CMD, abnormal function of the small microvessels within the heart). The purpose of the study is to understand ...


Mitral Valve Regurgitation

SAPIEN M3 System TransCatheter Mitral Valve ReplaCement via Transseptal Access  

The purpose of this study is to examine the safety and effectiveness of the investigational SAPIEN M3 System, a mitral valave replacement system, in patients with blood backflow (mitral regurgitation) across the mitral valve. The ...


Valvular Heart Disease

REPAIR MR

The purpose of this study is to evaluate the safety and effectiveness of an investigational medical device called the MitraClip Mitral Valve Repair System (MitraClip System) in patients with severe primary mitral regurgitation who are ...


Other

Tricuspid Regurgitation: Study of the TTVR Transfemoral System

This study focuses on individuals who have tricuspid regurgitation (TR), a condition in which the heart’s tricuspid valve does not close tightly, causing the blood to leak backwards. The study will evaluate the use of ...