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51 results found

Valvular Heart Disease

Triluminate Pivotal Study

This study focuses on patients who have severe or greater tricuspid regurgitation (TR) and who have symptoms due to heart failure despite being treated with currently available therapies. TR occurs when the leaflets of the ...

Atrial fibrillation and flutter

Using Electrical Nerve Stimulation to Control Atrial Fibrillation

This study focuses on individuals who have symptomatic paroxysmal atrial fibrillation (irregular heartbeat) that has not been successfully treated with medications. The purpose of the study is to determine whether sending mild electrical signals under ...

Genetic Disorders of the Cardiovascular System, Heart failure

Cytokinetics (CK-3773274)

This study focuses on adults who have obstructive hypertrophic cardiomyopathy (oHCM), abnormally thick heart muscle, and left ventricular outflow tract (LVOT) obstruction (a condition which interferes with the flow of blood in the heart). The ...

Cardiac Surgery

TRAVERSE: Transseptal vs Retrograde Aortic Ventricular Entry

The purpose of this study is to compare 2 methods that are each routinely performed as standards of care (a transseptal approach versus a retrograde approach) of performing a procedure, called ablation, to treat abnormal ...

ATTR-CM, Cardiac Amyloidosis

Cardiac Amyloidosis: Strategy to Improve Patient Outcomes by Silencing TTR Formation in ATTR-CM (TTRansform)

- To evaluate the effect of treatment with ION-682884 compared to placebo for 120 weeks on the composite endpoint of cardiovascular (CV) mortality and frequency of CV clinical events in patients with ATTR-CM receiving available ...