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PROGRESS Trial Continued Access Clinical Investigation Plan

The purpose of this study is to learn whether the SAPIEN 3 and SAPIEN 3 Ultra, and SAPIEN Ultra RESILIA Transcatheter Heart Valve are beneficial for patients with moderate, calcific aortic stenosis. Study procedures include ...


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GORE Ascending Stent Graft in the Treatment of Lesions of the Ascending Aorta

The purpose of this study is to evaluate the safety and effectiveness of a device called the GORE Ascending Stent Graft (ASG device) to treat aortic disease. The aorta is the main artery that carries ...


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Continued Access Study of the ShortCut Device

The purpose of this study to determine whether an experimental device called the ShortCut is safe and effective in people with a risk for coronary obstruction following a repeated bioprosthetic valve implantation. Coronary obstruction is ...


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Hearts Transplanted After Non-Ischemic Heart Preservation from Extended Donors

The purpose of this study is to evaluate whether non-ischemic heart preservation (NIHP) of extended criteria donor hearts using the XVIVO Heart Preservation System (XHPS) is a safe and effective way to preserve and transport ...


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Population Health Research_APSIRE-AF

To assess the effects of non-vitamin K oral anticoagulants (NOACs) versus no anticoagulation on the co-primary composite outcomes of 1. non-hemorrhagic stroke and systemic embolism, and 2. vascular mortality, and non-fatal non-hemorrhagic stroke, myocardial infarction, ...