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Tafamidis in Patients With Transthyretin-Mediated Amyloidosis Post Orthotopic Heart Transplantation

The purpose of this study is to determine whether tafamidis, an oral medication used to delay disease progression in adults with certain forms of transthyretin amyloidosis (ATTR), is effective in treating patients with heart transplants ...


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MagicTouch Sirolimus-Coated Balloon in Coronary Artery Lesions of In-Stent Restenosis

The purpose of this study is to evaluate the safety and effectiveness of an experimental drug-coated balloon system called the MagicTouch sirolimus-coated balloon for the treatment of coronary in-stent restenosis (recurrence of narrowing of a ...


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Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy

The goal of this study is to identify the best way to treat pulmonary embolism (blood clots in the lungs), specifically when there is a large amount of clot, but the patient’s blood pressure is ...


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AltaValve Pivotal Trial Protocol

The purpose of this study is to evaluate the safety and effectiveness of an experimental device called the AltaValve System in people with moderate-to-severe and severe mitral regurgitation. The study aims to determine whether the ...


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Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy

This study focuses on people who have been diagnosed with obstructive hypertrophic cardiomyopathy (oHCM), a condition in which the heart muscle thickens and blocks blood flow from the heart. The purpose of the study is ...