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Investigation of a Novel, Magnetically Levitated VAD for Refractory Left Ventricular Heart Failure (INNOVATE Trial)

The purpose of this study is to evaluate the safety and effectiveness of an experimental device called the BrioVAD System compared to the commercially available HeartMate 3 LVAS. Both the BrioVAD System and HeartMate 3 ...


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BELIEVERS

The novelty of the BELIEVERS trial lies in being the first adequately powered, randomized study to compare TAVR and SAVR with a bioprosthesis in BAV, incorporating imaging-guided stratification to optimize outcomes, incorporating robust patient-engagement approach ...


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Siegel Transcatheter Aortic Valve Replacement in Symptomatic Severe Aortic Stenosis

The purpose of this study is to evaluate the safety and effectiveness of the experimental Siegel Transcatheter Aortic Valve Replacement (TAVR) System for the treatment of adults who have symptomatic severe native calcific aortic stenosis. ...


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Coronary Intravascular Lithotripsy (IVL) Study

The purpose of this study is to evaluate the safety and effectiveness of an experimental device called the Abbott Coronary Intravascular Lithotripsy (IVL) System to widen sections of blood vessels in the heart that are ...


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Kiniksa_KPL-387-C212

Primary Objective Posology Study - To characterize the efficacy of the dosing regimens used to transition from prior pericarditis therapies to KPL-387 monotherapy in participants with well-controlled recurrent pericarditis (RP) on standard therapies. Primary Efficacy Endpoint ...