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Danicamtiv in Symptomatic Genetic and Familial Dilated Cardiomyopathy

The purpose of this study is to evaluate whether an experimental drug called danicamtiv improves heart function in adults with dilated cardiomyopathy compared to current standard treatment. DCM is a condition in which the heart ...


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Investigation of a Novel, Magnetically Levitated VAD for Refractory Left Ventricular Heart Failure (INNOVATE Trial)

The purpose of this study is to evaluate the safety and effectiveness of an experimental device called the BrioVAD System compared to the commercially available HeartMate 3 LVAS. Both the BrioVAD System and HeartMate 3 ...


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BELIEVERS

The novelty of the BELIEVERS trial lies in being the first adequately powered, randomized study to compare TAVR and SAVR with a bioprosthesis in BAV, incorporating imaging-guided stratification to optimize outcomes, incorporating robust patient-engagement approach ...


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AGENT Drug-Coated Balloon for Stent Avoidance in PCI for De Novo Coronary Artery Disease

This study will compare the safety and effectiveness of an experimental device called the AGENT Paclitaxel Coated Balloon Catheter (AGENT DCB) to standard-of-care treatment in patients with untreated coronary artery disease caused by narrowing blood ...


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Siegel Transcatheter Aortic Valve Replacement in Symptomatic Severe Aortic Stenosis

The purpose of this study is to evaluate the safety and effectiveness of the experimental Siegel Transcatheter Aortic Valve Replacement (TAVR) System for the treatment of adults who have symptomatic severe native calcific aortic stenosis. ...