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48 results found

Genetic Disorders of the Cardiovascular System, Heart failure

Cytokinetics (CK-3773274)

This study focuses on adults who have obstructive hypertrophic cardiomyopathy (oHCM), abnormally thick heart muscle, and left ventricular outflow tract (LVOT) obstruction (a condition which interferes with the flow of blood in the heart). The ...

Cardiac Surgery

TRAVERSE: Transseptal vs Retrograde Aortic Ventricular Entry

The purpose of this study is to compare 2 methods that are each routinely performed as standards of care (a transseptal approach versus a retrograde approach) of performing a procedure, called ablation, to treat abnormal ...

ATTR-CM, Cardiac Amyloidosis

Cardiac Amyloidosis: Strategy to Improve Patient Outcomes by Silencing TTR Formation in ATTR-CM (TTRansform)

- To evaluate the effect of treatment with ION-682884 compared to placebo for 120 weeks on the composite endpoint of cardiovascular (CV) mortality and frequency of CV clinical events in patients with ATTR-CM receiving available ...

Valvular Heart Disease

TRISCEND II Pivotal Trial

This study focuses on adults who have tricuspid regurgitation (TR), a condition in which the heart's tricuspid valve does not close tightly, causing blood to flow backwards in the wrong direction. The purpose of the ...


Optimizer Smart PAS

The MDAC panel recommended a post-approval study that evaluates data such as cardiac outcomes, quality of life, mortality, and functionality. Long term data are also needed to assess complication rates and potential interactions with other ...