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16 results found


Bones and Joints, Breast, Cervix, Colon, Esophagus, Kidney, Liver, Lung ...

MacroGenics, Inc., CP-MGC026-01, Phase 1/1b, Open Label, Multi-Center, Solid Tumors, MGC026

Primary Objective: To characterize the safety, tolerability, dose-limiting toxicities (DLTs), and maximum tolerated dose (MTD) or maximum administered dose (MAD) (if no MTD is defined) of MGC026. Secondary Objective(s): To characterize the systemic pharmacokinetics (PK) of ...


Corpus Uteri, Ovary

Selumetinib and Olaparib or Selumetinib Alone in Ovarian and Endometrial Cancers

This study focuses on people who have recurrent or persistent ovarian or endometrial cancer and whose cancer has a change in the gene family called RAS genes. The purpose of the study is to compare ...


Breast, Kidney, Lung, Multiple Myeloma, Other Digestive Organ, Ovary, Pancreas ...

QXL138AM in Locally Advanced Unresectable and/or Metastatic Solid Tumors and Multiple Myeloma

The purpose of this study is to evaluate the safety and tolerability of an experimental drug called QXL138AM in people with advanced solid tumors and multiple myeloma. There are 2 parts to this study. In ...


Breast, Cervix, Esophagus, Kidney, Liver, Lung, Melanoma, Other Female Genital ...

Phase 1/2 Study of CRB-601 in Patients With Advanced Solid Tumors

The purpose of this study is to determine whether an experimental drug called CRB-601 can help people with advanced solid tumors (cancer). The study aims to evaluate how well the drug is tolerated and identify ...


Ovary

Comparing the Non-Inferiority of Salpingectomy to Salpingo-Oophorectomy to Reduce the Risk of Ovarian Cancer

This study aims to determine whether 2 surgical procedures are no different for ovarian cancer risk reduction in individuals with BRCA1 mutations who have completed childbearing. (Mutations in the BRCA1 gene are associated with a ...