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152 results found


Ovary

Comparing the Non-Inferiority of Salpingectomy to Salpingo-Oophorectomy to Reduce the Risk of Ovarian Cancer

This study aims to determine whether 2 surgical procedures are no different for ovarian cancer risk reduction in individuals with BRCA1 mutations who have completed childbearing. (Mutations in the BRCA1 gene are associated with a ...


Breast

Da Vinci SP Surgical System in Nipple-Sparing Mastectomy

The purpose of this clinical study is to collect data about the use of a robotic device called the da Vinci Single-Port (SP) Surgical System in nipple-sparing mastectomy (NSM) procedures. NSM is a surgery for ...


Lung, Rectum

HPN328 in Advanced Cancers Associated with DLL3

The purpose of this study is to test the safety and effects of an experimental drug called HPN328 alone and in combination with another drug, atezolizumab, in patients who have small cell lung cancer or ...


Breast

Shorter Anthracycline-Free Chemo Immunotherapy in Early Triple-Negative Breast Cancer

The purpose of this study is to compare the standard-of-care chemo-immunotherapy (carboplatin/paclitaxel followed by adriamycin/cyclophosphamide plus pembrolizumab, given in 6 months) treatment for early-stage, triple-negative breast cancer to a shorter non-anthracycline chemo-immunotherapy treatment (carboplatin docetaxel ...


Breast, Cervix, Colon, Esophagus, Kidney, Liver, Lung, Melanoma, Other Female ...

GIM-122 as a Single Agent in Advanced Solid Malignancies

The purpose of this study is to evaluate an investigational drug called GIM-122 in people who have been diagnosed with an advanced or malignant tumors. These patients have tumors that were eligible to be treated ...