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157 results found


Other Female Genital, Unknown Sites

Neratinib Alone or in Combination with Palbociclib in HER2+ Cancers and Other Solid Tumors

This study focuses on individuals who have recurrent or persistent cancer and whose cancer expresses a protein called HER2 (human growth factor receptor 2). The purpose of the study is to determine whether a combination ...


Other

Phase II Study of Unresectable Hepatocellular Carcinoma and Cirrhosis

The purpose of this study is to evaluate the effects of combined immunotherapy regimens (atezolizumab with bevacizumab) in patients with inoperable liver cancer and liver disease (cirrhosis). Participants may receive atezolizumab alone (if they are ...


Breast

Adjuvant Sacituzumab Govitecan and Pembrolizumab in Triple-Negative Breast Cancer

The purpose of this study is to evaluate an experimental drug called sacituzumab govitecan in combination with pembrolizumab, or pembrolizumab with or without capecitabine, in people with high-risk, early triple-negative breast cancer without mutations (changes) ...


Lymphoid Leukemia, Non-Hodgkin Lymphoma

AZD0486 in Adolescents and Adults With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

The purpose of this study is to learn more about an experimental drug called AZD0486 and determine whether it will be safe, tolerable, and effective in treating B-cell acute lymphoblastic leukemia (B-ALL). AZD0486 is ...


Urinary Bladder

Bladder Preservation for Patients With Muscle Invasive Bladder Cancer With Variant Histology

The goal of this study is to evaluate a treatment called trimodal therapy after a course of neoadjuvant therapy (treatment given as a first step to shrink a tumor before main treatment) as a way ...